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Science:构建更好的人类癌症小鼠模型

2015-01-04 14:19  
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Science封面故事:构建更好的人类癌症小鼠模型

摘要 : 2014年10月3日Science杂志封面故事:为了让小鼠更能体现出人类癌症,研究人员正在构建特定患者的癌症“化身”,或像人类一样自发形成肿瘤的工程小鼠。

2014年10月3日Science杂志封面故事:为了让小鼠更能体现出人类癌症,研究人员正在构建特定患者的癌症“化身”,或像人类一样自发形成肿瘤的工程小鼠。这项工作标志了癌症生物学的一个巨大变化,以及新的小鼠模型为更人性化的治疗铺平道路。

Hope in a mouse.

Jennifer Couzin-Frankel

Science 3 October 2014: Vol. 346 no. 6205 pp. 28-29
DOI: 10.1126/science.346.6205.28

Feature

Champions Oncology is a biotech company pushing the limits of biology: It’s selling personalized mouse models to cancer patients. The company creates "avatar" mice with samples of a patient’s tumor and some normal tissue, building a cohort of animals in which to test drugs. The hope is that any therapies that help the mice will also help that particular patient. Champions is drawing praise and criticism, and sparking debate about whether avatar mice are ready for patient use and whether it’s appropriate for families to pay thousands of dollars for a strategy that is still experimental. At the same time, others say the mice have so far shown they can predict responses to drugs in people, and that patients with few options should have the right to try them. There are many hurdles along the way. They include coaxing tumor to engraft in a mouse, and the several months it usually takes to build the animals and test the drugs. Many patients have little time to wait.

The littlest patient.Jennifer Couzin-Frankel.DOI: 10.1126/science.346.6205.24

Cancer researchers have long been frustrated by a dismal statistic that plagues their field: Ninety percent of drugs that shine in mice fail in people. Now, mouse models are undergoing an overhaul in an effort to change that. At Columbia University, Kenneth Olive is working with mice that are genetically engineered to spontaneously develop pancreatic cancer; in his "mouse hospital," the animals undergo regular ultrasounds, surgeries, and treatments in the hopes of clarifying the biology of the disease and how best to treat it in people. Another model involves grafting tumor tissue from cancer patients into individual mice. Although there’s much excitement that these cutting-edge mouse models will prove a more reliable guide, like all animal models they come with drawbacks, and are expensive and time-consuming to work with.

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